Publications
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NTB-A and 2B4 Natural Killer Cell Receptors Modulate the Capacity of a Cocktail of Non-Neutralizing Antibodies and a Small CD4-Mimetic to Eliminate HIV-1-Infected Cells by Antibody-Dependent Cellular Cytotoxicity.
Marchitto L, Tauzin A, Benlarbi M, Beaudoin-Bussières G, Dionne K, Bélanger É, Chatterjee D, Bourassa C, Medjahed H, Yang D, Chiu TJ, Chen HC, Iii ABS, Richard J, Finzi A. Viruses. 2024 Jul 20;16(7):1167. doi: 10.3390/v16071167. PMID: 39066329
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity.
Tauzin A, Marchitto L, Bélanger É, Benlarbi M, Beaudoin-Bussières G, Prévost J, Yang D, Chiu T-J, Chen H-C, Bourassa C, Medjahed H, Korzeniowski MK, Gottumukkala S, Tolbert WD, Richard J, Smith AB 3rd, Pazgier M, Finzi A. J Virol. 2024 Sep 4:e0096024. doi: 10.1128/jvi.00960-24. PMID: 39230306
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity.
Marchitto L, Richard J, Prévost J, Tauzin A, Yang D, Chiu T-J, Chen H-C, Díaz-Salinas MA, Nayrac M, Benlarbi M, Beaudoin-Bussières G, Anand SP, Dionne K, Bélanger É, Chatterjee D, Medjahed H, Bourassa C, Tolbert WD, Hahn BH, Munro JB, Pazgier M, Smith AB 3rd, Finzi A. J Virol. 2024 Sep 9:e0101624. doi: 10.1128/jvi.01016-24. PMID: 39248460
Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption.
Pereira Ribeiro S, Strongin Z, Soudeyns H, Ten-Caten F, Ghneim K, Pacheco Sanchez G, Xavier de Medeiros G, Del Rio Estrada PM, Pelletier AN, Hoang T, Nguyen K, Harper J, Jean S, Wallace C, Balderas R, Lifson JD, Raghunathan G, Rimmer E, Pastuskova C, Wu G, Micci L, Ribeiro RM, Chan CN, Estes JD, Silvestri G, Gorman DM, Howell BJ, Hazuda DJ, Paiardini M, Sekaly RP. Nat Immunol. 2024 Sep 12. doi: 10.1038/s41590-024-01952-4. PMID: 39266691.
Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells.
Sáez-Cirión A, Mamez AC, Avettand-Fenoel V, Nabergoj M, Passaes C, Thoueille P, Decosterd L, Hentzien M, Perdomo-Celis F, Salgado M, Nijhuis M, Melard A, Gardiennet E, Lorin V, Monceaux V, Chapel A, Gourves M, Lechartier M, Mouquet H, Wensing A, Picado JM, Yerly S, Rougemont M, Calmy A. Nat Med. 2024 Sep 2. doi: 10.1038/s41591-024-03277-z. PMID: 39222660
Zhang Z, et al. Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein pretriggered conformation. J Virol. 2023 Sep 28;97(9):e0059223. doi: 10.1128/jvi.00592-23. Epub 2023 Sep 11. PMID: 37696048.
Samer S, et al. Lymph-node based CD3+CD20+ cells emerge from membrane exchange between T follicular helper cells and B cells and increase their frequency following Simian Immunodeficiency Virus infection. J Virol. 2023 Jun 29;97(6):e0176022. doi: 10.1128/jvi.01760-22. Epub 2023 May 23. PMID: 37223960.
Chandrasekar AP, et al. The BCL-2 inhibitor Venetoclax augments immune effector function mediated by Fas lognad TRAIL, and Perforin/Granzyme B, resulating in reduced plasma viremia and decreased HIV reservoir size during acute HIV infection in a humanized mouse model. J Virol. 2022 Dec 21;96(24):e0173022. doi: 10.1128/jvi.01730-22. Epub 2022 Nov 30. PMID: 36448802.