Therapeutic CD8+ T cell tissue retention and immunomodulation during ART interruption fail to prevent SIV rebound

Immune-mediated strategies to solving the HIV reservoir problem Nat Rev Immunol

EZH2 inhibition mitigates HIV immune evasion, reduces reservoir formation, and promotes skewing of CD8+ T cells toward less-exhausted phenotypes

Safety, pharmacokinetics, and biological activity of CD4-mimetic BNM-III-170 in SHIV- infected rhesus macaques

Inhibition of ALKBH5 demethylase of m⁶A pathway potentiates HIV-1 reactivation from latency

A gp41 HR2 residue modulates the susceptibility of HIV-1 envelope glycoproteins to small molecule inhibitors targeting gp120

A genetic fingerprint associated with durable HIV remission after interruption of antiretroviral treatment: ANRS VISCONTI/PRIMO

Nuclear retention of unspliced HIV-1 RNA as a reversible post-transcriptional block in latency

IL-21 and anti-α4β7 dual therapy during ART promotes immunological and microbiome responses in SIV-infected macaques

Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild- type CCR5 donor cells

Profound reduction of HIV-1 reservoir cells over 3 decades of antiretroviral therapy started in early infancy

CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies

Footprints of innate immune activity during HIV-1 reservoir cell evolution in early-treated infection

Stoichiometry of HIV-1 Envelope Glycoprotein Protomers with Changes That Stabilize or Destabilize the Pretriggered Conformation

The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity

Conformations of membrane human immunodeficiency virus (HIV-1) envelope glycoproteins solubilized in Amphipol A18 lipid-nanodiscs

Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in the presence of CD4-mimetics

Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption

The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC

Metformin facilitates viral reservoir reactivation and their recognition by anti-HIV-1 envelope antibodies

Retinoic acid enhances HIV-1 reverse transcription and transcription in macrophages via mTOR-modulated mechanisms

NTB-A and 2B4 Natural Killer Cell Receptors Modulate the Capacity of a Cocktail of Non-Neutralizing Antibodies and a Small CD4-Mimetic to Eliminate HIV-1-Infected Cells by Antibody-Dependent Cellular Cytotoxicity

Distinct SIV-specific CD8⁺ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence

The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity

Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics

Immune targeting of HIV-1 reservoir cells: a path to elimination strategies and cure

Membrane HIV-1 envelope glycoproteins stabilized more strongly in a pretriggered conformation than natural virus Envs

"Block and lock" viral integration sites in persons with drug-free control of HIV-1 infection

Plasmatic HIV-1 soluble gp120 is associated with correlates of immune dysfunction and inflammation in ART-treated individuals with undetectable viremia

Proliferation of HIV-1 reservoir cells: The delusion of infinite growth

Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner? Pathog Immun

The HIV-1 reservoir landscape in persistent elite controllers and transient elite controllers

Inhibition of human immunodeficiency virus (HIV-1) infectivity by expression of poorly or broadly neutralizing antibodies against Env in virus-producing cells

Metformin Enhances Antibody-Mediated Recognition of HIV-Infected CD4⁺ T-Cells by Decreasing Viral Release

Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a

Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells

IL-15-dependent immune crosstalk between natural killer cells and dendritic cells in HIV-1 elite controllers

Preferential selection of viral escape mutants by CD8+ T cell ‘sieving’ of SIV reactivation from latency

V3 tip determinants of susceptibility to inhibition by CD4-mimetic compounds in natural clade A human immunodeficiency virus (HIV-1) envelope glycoproteins

Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy

Timing of initiation of anti-retroviral therapy predicts post-treatment control of SIV replication

Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein pretriggered conformation

Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity

Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy

Application of ultrasensitive digital ELISA for p24 enables improved evaluation of HIV-1 reservoir diversity and growth kinetics in viral outgrowth assays

Lymph-Node-Based CD3⁺ CD20⁺ Cells Emerge from Membrane Exchange between T Follicular Helper Cells and B Cells and Increase Their Frequency following Simian Immunodeficiency Virus Infection

Identification of aryl hydrocarbon receptor as a barrier to HIV-1 infection and outgrowth in CD4⁺ T cells

Temsavir Modulates HIV-1 Envelope Conformation by Decreasing Its Proteolytic Cleavage

Piperidine CD4-Minetic compounds expose vulnerable Env epitopes sensitizing HIV-1-infected cells to ADCC

CD8⁺ T cells promote HIV latency by remodeling CD4⁺ T cell metabolism to enhance their survival, quiescence, and stemness

HIV-1 DNA and Immune Activation Levels Differ for Long-Lived T-Cells in Lymph Nodes, Compared with Peripheral Blood, during Antiretroviral Therapy

Characterization of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Conformational States on Infectious Virus Particles

Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody- dependent cellular cytotoxicity

HIV-1 reservoir evolution in infants infected with clade C from Mozambique

Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity

Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates

The latent SIV reservoir under ART is established independent of CD8+ lymphocyte control

Phenotypic signatures of immune selection in HIV-1 reservoir cells

Repurposing BCL-2 and Jak 1/2 inhibitors: Cure and treatment of HIV-1 and other viral infections

Structural and functional characterization of indane-core CD4-mimetic compounds substituted with heterocyclic amines

The BCL-2 inhibitor Venetoclax augments immune effector function mediated by Fas lognad TRAIL, and Perforin/Granzyme B, resulating in reduced plasma viremia and decreased HIV reservoir size during acute HIV infection in a humanized mouse model

HIV-1 Vpu restricts Fc-mediated effector functions in vivo

No evidence that circulating HIV-specific immune responses contribute to persistent inflammation and immune activation in persons on long- term ART

Limited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques

Characterization of Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Variants Selected for Resistance to a CD4-Mimetic Compound

An ordeal that does not heal: understanding barriers to a cure for HIV-1 infection

Potential multi-modal effects of provirus integration on HIV-1 persistence: lessons from other viruses

The role of Cd101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence

Temsavir treatment of HIV-1-infected cells decreases envelope glycoprotein recognition by broadly neutralizing antibodies

Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control

Novel role of UHRF1 in the epigenetic repression of the latent HIV-1

Novel Compound Inhibitors of HIV-1 NL4-3 Vpu

Interleukin-10 contributes to reservoir establishment and persistence in antiretroviral therapy-treated, SIV-infected macaques

Novel role of UHRF1 in the epigenetic repression of the latent HIV-1

Hide and seek: for HIV-infected CD4+ T cells, playing well comes with maturity

Detection of the HIV-1 Accessory Proteins Nef and Vpu by Flow Cytometry Represents a New Tool to Study Their Functional Interplay within a Single Infected CD4⁺ T Cell

Detection of the HIV-1 accessory proteins Nef and Vpu by flow cytometry represents a new tool to study their functional interplay within a single infected CD4+ T cell

Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses

Single center, open label dose escalating trial evaluating once weekly oral ixazomib in ART-suppressed, HIV positive adults and effects on HIV reservoir size in vivo.

HIV-1 envelope glycoproteins proteolytic cleavage protects infected cells from ADCC mediated by plasma from infected individuals

Targeting Macrophage Dysregulation for Viral Infections: Novel Targets for Immunomodulators